Class

Agent

Dose

Symptomatic therapy: Benzodiazepines [122]

 

Diazepam [24]

Clonazepam [92,117]

Alprazolam

Lorazepam

5-100 mg/day

2.56 mg/day

24 mg/day

6 mg/day

Muscle relaxants

Tizanidine [116]

Baclofen [144]

ITB [139]

Dantrolene

Botulinum toxin A [5,41]

636 mg/day

1060 mg/day

50150 μg/day

200400 mg/day

Variable

Cannabis

THC-CBD [193]

Variable

Antiepileptic  drugs

 

 

 

 

 

Levetiracetam [166]

Pregabaline

Gabapentin [189]

Tiagabine [127]

Valproate [177]

Vigabatrin [190]

5001000 mg twice a day

75150 mg twice a day

300900 mg three times day

48 mg once or twice a day

300600 mg twice daily

5001500 mg twice daily

 Immunotherapy

 

 

 

 

 

 

IVIg [51,32]

Rituximab [100]

Plasma exchange [113,135]

Corticosteroids [62,141]

Mycophenolate mofetil [64]

Tacrolimus [130]

Cyclophosphamide [191]

Azathioprine [176]
Methotrexate

1 g/kg body weight/month.

2 infusions of 1 g each, every two weeks

5 PE in 12 weeks

50-60 mg/day

2 g/day

3 mg/day

1-5 mg/kg/day

12.5 mg/kg/day

15-20 mg/day

Interventional therapy

 

Anesthesia [169,71]

Spinal cord Stimulation [187]